Inhibition of Cell Proliferation by Houttuynia cordata Extract on Gastric Cancer Cells via Induction of Apoptosis

Houttuynia cordata Thunb. is an edible and medicinal plant that belongs to the family of Saururaceae widely distributes in Eastern Asia countries. H. have been reported as a promising anticancer agent against various cancer cells. This study was determine anti-proliferative effect extract on gastric cells using vitro experimental model. The cytotoxicity examined via 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, while cell migration conducted by wound healing assay. gene expression level measured real time PCR. result showed butanol exhibited highest activity BGC-823 with IC50 value 193 µg/ml. Moreover, assay determined suppressive capacity at concentration 50 Notably, treatment (50 µg/ml) able up-regulate mRNA apoptosis-mediated signaling molecules, including caspase-8, Bax, caspase-9, caspase-3 These results indicate possesses inhibitory tumor development metastasis induction process programmed death.